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New work from Los Alamos National Laboratory shows promise for stemming the advance of tuberculosis (TB) by revealing how the bacterium interacts with its human hosts and thus providing a new pathway for early detection in patients.
A recent publication from the Los Alamos Biosensor Team describes the association of a key tuberculosis virulence factor, lipoarabinomannan (LAM) with human high-density lipoproteins (HDL) in blood. “Understanding the pathophysiology of tuberculosis, and the distribution of pathogen-associated molecules in the host, is essential to developing efficient methods of intervention,” said Harshini Mukundan, corresponding author on the paper.
“Association of lipoarabinomannan with high density lipoprotein in blood: Implications for diagnostics” Tuberculosis 93 (2013) was published April 3rd, 2013, in the journal Tuberculosis.
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