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Two Los Alamos National Laboratory scientists are among the team recently funded to explore ways to create the precise immune factors needed for effective vaccines against HIV.
The Duke University-led consortium will largely concentrate on inducing broadly neutralizing antibodies that can prevent HIV-1 infection, as well as on generating protective T-cell and innate immune system responses.
“A vaccine-elicited broadly neutralizing antibody response has the potential to block HIV infection; T-cell responses will support that response, and are likely to be able to help control and contain the virus if it breaks through the neutralizing antibody response,” said Bette Korber, one of the LANL researchers.
“Some HIV infected individuals eventually make good neutralizing responses during their infection,” she noted. The scientists will use the body’s occasional ability to create these antibodies as roadmaps for candidate vaccines to stimulate protective antibody responses. Los Alamos scientists from the theoretical biology group will provide analyses and design.
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